SARS–CoV-2 infection of the placenta

Hosier, Hillary; Farhadian, Shelli; Morotti, Raffaella; Deshmukh, Uma; Lu-Culligan, Alice; Campbell, Katherine; Yasumoto, Yuki; Vogels, Chantal B. F.; Casanovas‐Massana, Arnau; Vijayakumar, Pavithra; Geng, Bertie; Odio, Camila D.; Fournier, John; Brito, Anderson F.; Fauver, Joseph R.; Liu, Feimei; Alpert, Tara; Tal, Reshef; Szigeti‐Buck, Klara; Perincheri, Sudhir; Larsen, Christopher P.; Gariepy, Aileen M.; Aguilar, Gabriela; Fardelmann, Kristen L.; Harigopal, Malini; Taylor, Hugh S.; Pettker, Christian M.; Wyllie, Anne L.; Cruz, Charles S. Dela; Ring, Aaron M.; Grubaugh, Nathan D.; Ko, Albert I.; Horváth, Tamás L.; Iwasaki, Akiko; Reddy, Uma M.; Lipkind, Heather S.

doi:10.1172/jci139569

articleJournal of Clinical InvestigationJun 23, 2020BRONZE OA

SARS–CoV-2 infection of the placenta

HHHillary Hosier SFShelli Farhadian RMRaffaella Morotti UDUma Deshmukh ALAlice Lu-Culligan

Office of Infectious Diseases · Yale University · +1 more institution

PubMed

Indexed incrossrefdoajpubmed

Abstract

BACKGROUNDThe effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.METHODSWe analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection.RESULTSSARS-CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no…

Citation impact

492

total citations

FWCI: 42.21
Percentile: 100%
References: 31

Citations per year

Authors

36

Topics & keywords

Topics

Keywords

Pregnancy
Preeclampsia
Coronavirus disease 2019 (COVID-19)
Placenta
Medicine
Placental abruption
Obstetrics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.