Platelet gene expression and function in patients with COVID-19

There is an urgent need to understand the pathogenesis of coronavirus disease 2019 (COVID-19). In particular, thrombotic complications in patients with COVID-19 are common and contribute to organ failure and mortality. Patients with severe COVID-19 present with hemostatic abnormalities that mimic disseminated intravascular coagulopathy associated with sepsis, with the major difference being increased risk of thrombosis rather than bleeding. However, whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters platelet function to contribute to the pathophysiology of COVID-19 remains unknown. In this study, we report altered platelet gene expression and functional responses in patients…

• UD
  U.S. Department of Veterans Affairs

  Award: I01 CX001696
• UO
  University of Utah

  Award: P30CA042014
• HC
  Huntsman Cancer Institute

  Award: P30CA042014
• FW
  Fonds Wetenschappelijk Onderzoek

  Award: 12U7818N
• VR
  Vlaamse regering
• NI
  National Institutes of Health

  Awards: 1S10RR026802, P30CA042014, K01AG059892, 1S10RR026802-01
• CS
  Clinical Science Research and Development
• NH
  National Heart, Lung, and Blood Institute

  Awards: R01HL130541, R01HL135265, R01HL142804
• NC
  National Cancer Institute

  Awards: 1S10RR026802-01, P30CA042014
• NI
  National Institute of General Medical Sciences
• NI
  National Institute of Child Health and Human Development
• EK
  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  Award: R01093826