articleProceedings of the National Academy of SciencesJun 22, 2020HYBRID OA

Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

MIMasaki ImaiKIKiyoko Iwatsuki‐HorimotoMHMasato HattaSLSamantha LoeberPHPeter Halfmann

The University of Tokyo · University of Wisconsin–Madison · +3 more institutions

PubMed
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Abstract

At the end of 2019, a novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) was detected in Wuhan, China, that spread rapidly around the world, with severe consequences for human health and the global economy. Here, we assessed the replicative ability and pathogenesis of SARS-CoV-2 isolates in Syrian hamsters. SARS-CoV-2 isolates replicated efficiently in the lungs of hamsters, causing severe pathological lung lesions following intranasal infection. In addition, microcomputed tomographic imaging revealed severe lung injury that shared characteristics with SARS-CoV-2-infected human lung, including severe, bilateral, peripherally distributed, multilobular ground glass opacity, and…

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Topics & keywords

Topics
Keywords
  • Mesocricetus
  • Virology
  • Hamster
  • Syrian hamsters
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  • Pneumonia
  • Coronavirus disease 2019 (COVID-19)
  • Neutralizing antibody
UN Sustainable Development Goals
  • Good health and well-being
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