cGAS-STING, an important pathway in cancer immunotherapy

Cytosolic DNA sensing, the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway, is an important novel role in the immune system. Multiple STING agonists were developed for cancer therapy study with great results achieved in pre-clinical work. Recent progress in the mechanical understanding of STING pathway in IFN production and T cell priming, indicates its promising role for cancer immunotherapy. STING agonists co-administrated with other cancer immunotherapies, including cancer vaccines, immune checkpoint inhibitors such as anti-programmed death 1 and cytotoxic T lymphocyte-associated antigen 4 antibodies, and adoptive T cell transfer therapies, would hold a promise of treating medium…

• NN
  National Natural Science Foundation of China

  Awards: 2017ZZ02012, 81802255, 2016YFC0902300, fkyq1901
• SA
  Science and Technology Commission of Shanghai Municipality

  Awards: 81802255, fkyq1901, 16JC1405900
• SS
  Shanghai Shen Kang Hospital Development Center
• SP
  Shanghai Pulmonary Hospital

  Awards: 81802255, 2017ZZ02012, fkyq1901