Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

Middleton, Elizabeth A.; He, Xue‐Yan; Denorme, Frederik; Campbell, Robert A.; Ng, David; Salvatore, Steven; Mostyka, Maria; Baxter-Stoltzfus, Amelia; Borczuk, Alain; Loda, Massimo; Cody, Mark J.; Manne, Bhanu Kanth; Portier, Irina; Harris, Estelle S.; Petrey, Aaron C.; Beswick, Ellen J.; Caulin, Aleah F.; Iovino, Anthony J.; Abegglen, Lisa M.; Weyrich, Andrew S.; Rondina, Matthew T.; Egeblad, Mikala; Schiffman, Joshua D.; Yost, Christian C.

doi:10.1182/blood.2020007008

articleBloodJun 29, 2020BRONZE OA

Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome

EAElizabeth A. Middleton XHXue‐Yan He FDFrederik Denorme RARobert A. Campbell DNDavid Ng

University of Utah · Cold Spring Harbor Laboratory · +5 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

COVID-19 affects millions of patients worldwide, with clinical presentation ranging from isolated thrombosis to acute respiratory distress syndrome (ARDS) requiring ventilator support. Neutrophil extracellular traps (NETs) originate from decondensed chromatin released to immobilize pathogens, and they can trigger immunothrombosis. We studied the connection between NETs and COVID-19 severity and progression. We conducted a prospective cohort study of COVID-19 patients (n = 33) and age- and sex-matched controls (n = 17). We measured plasma myeloperoxidase (MPO)-DNA complexes (NETs), platelet factor 4, RANTES, and selected cytokines. Three COVID-19 lung autopsies were examined for NETs and platelet involvement.…

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Topics & keywords

Topics

Keywords

Neutrophil extracellular traps
ARDS
Immunology
Medicine
Respiratory distress
Platelet activation
Ex vivo
Platelet

UN Sustainable Development Goals

Good health and well-being

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