Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues

Lopes‐Ramos, Camila M.; Chen, Cho-Yi; Kuijjer, Marieke L.; Paulson, Joseph N.; Sonawane, Abhijeet R.; Fagny, Maud; Platig, John; Glass, Kimberly; Quackenbush, John; DeMeo, Dawn L.

doi:10.1016/j.celrep.2020.107795

articleCell ReportsJun 1, 2020GOLD OA

Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues

CMCamila M. Lopes‐Ramos CCCho-Yi Chen MLMarieke L. Kuijjer JNJoseph N. Paulson ARAbhijeet R. Sonawane

Harvard University · National Yang Ming Chiao Tung University · +9 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific gene regulatory networks in 29 human healthy tissues using 8,279 whole-genome expression profiles from the Genotype-Tissue Expression (GTEx) project. We find sex-biased regulatory network structures in each tissue. Even though most transcription factors (TFs) are not differentially expressed between males and females, many have sex-biased regulatory targeting patterns. In each tissue, genes that are differentially targeted by TFs between the sexes are enriched for tissue-related functions and…

Citation impact

534

total citations

FWCI: 25.76
Percentile: 100%
References: 52

Citations per year

Authors

10

Topics & keywords

Topics

Keywords

Biology
Gene regulatory network
Gene
Regulation of gene expression
Disease
Gene expression
Transcription factor
Genetics

No related works found for this paper.