Nickel-Catalyzed Enantioselective Reductive Cross-Coupling Reactions

Nickel-catalyzed reductive cross-coupling reactions have emerged as powerful methods to join two electrophiles. These reactions have proven particularly useful for the coupling of sec-alkyl electrophiles to form stereogenic centers; however, the development of enantioselective variants remains challenging. In this Perspective, we summarize the progress that has been made toward Ni-catalyzed enantioselective reductive cross-coupling reactions.

• NI
  National Institute of General Medical Sciences

  Award: R35GM118191-01
• DO
  Division of Graduate Education

  Award: DGE-1144469