Mitophagy, Mitochondrial Homeostasis, and Cell Fate
Nankai University · Chinese Academy of Medical Sciences & Peking Union Medical College · +6 more institutions
Abstract
Mitochondria are highly plastic and dynamic organelles that have graded responses to the changing cellular, environmental, and developmental cues. Mitochondria undergo constant mitochondrial fission and fusion, mitochondrial biogenesis, and mitophagy, which coordinately control mitochondrial morphology, quantity, quality, turnover, and inheritance. Mitophagy is a cellular process that selectively removes the aged and damaged mitochondria via the specific sequestration and engulfment of mitochondria for subsequent lysosomal degradation. It plays a pivotal role in reinstating cellular homeostasis in normal physiology and conditions of stress. Damaged mitochondria may either instigate innate immunity through the…
Citation impact
- FWCI
- 28.17
- Percentile
- 100%
- References
- 189
Authors
6- KMKaili Ma
Nankai University
- GCGuo Chen
Nankai University
- WLWenhui Li
Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou Institute of Systems Medicine
- OKOliver Kepp
Sorbonne Université, Centre de Recherche des Cordeliers, Université Paris Cité, Institut Gustave Roussy, Inserm
- YZYushan ZhuCorresponding
Nankai University
Topics & keywords
- Mitophagy
- Cell fate determination
- Homeostasis
- Mitochondrion
- Cell biology
- Biology
- Neuroscience
- Genetics