Half a century of amyloids: past, present and future

Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-β architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal…

• NS
  National Science Foundation
• HH
  Howard Hughes Medical Institute
• AS
  Alzheimer's Society
• DF
  Deutsche Forschungsgemeinschaft

  Award: FA 456/27
• NI
  National Institutes of Health

  Award: R01GM118651
• MR
  Medical Research Council
• EA
  Engineering and Physical Sciences Research Council

  Awards: EP/L020599, Platform grant EP/L020599/1, EP/L020599/1, EP/L020599/1
• BA
  Biotechnology and Biological Sciences Research Council
• AR
  Australian Research Council

  Award: No. CE140100036