reviewInternational Journal of Molecular SciencesJul 6, 2020GOLD OA

NRF2, a Transcription Factor for Stress Response and Beyond

FHFeng HeXRXiaoli RuTWTao Wen

University of California San Diego · Capital Medical University · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges. In addition to antioxidant responses, NRF2 is involved in many other cellular processes, including metabolism and inflammation, and its functions are beyond the originally envisioned. NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cell's response and adaptation to various pathological…

Citation impact

1,672
total citations
FWCI
50.51
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100%
References
150
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Authors

3

Topics & keywords

Topics
Keywords
  • Proteostasis
  • Transcription factor
  • Cell biology
  • Biology
  • KEAP1
  • Cellular stress response
  • Inflammation
  • Oxidative stress
UN Sustainable Development Goals
  • Good health and well-being
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