reviewFrontiers in PhysiologyJul 2, 2020GOLD OA

Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases

MSMehdi Sharifi‐RadNVN. V. Anil KumarPZPaolo ZuccaEMElena Maria VaroniLDLuciana Dini

Kerman University of Medical Sciences · Manipal Academy of Higher Education · +16 more institutions

PubMed
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Abstract

Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies…

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Topics & keywords

Topics
Keywords
  • Oxidative stress
  • Antioxidant
  • Oxidative phosphorylation
  • Diabetes mellitus
  • Medicine
  • Oxidative damage
  • Pathogenesis
  • Bioinformatics
UN Sustainable Development Goals
  • Good health and well-being
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