Nickel-Catalyzed Dicarbofunctionalization of Alkenes

1,2-Dicarbofunctionalization of alkenes has emerged as an efficient synthetic strategy for preparing substituted molecules by coupling readily available alkenes with electrophiles and/or nucleophiles. Nickel complexes serve as effective catalysts owing to their tendency to undergo facile oxidative addition and slow β-hydride elimination, and their capability to access both two-electron and radical pathways. Two-component alkene functionalization reactions have achieved high chemo-, regio-, and stereoselectivities by tethering one of the coupling partners to the alkene substrate. Three-component reactions, however, often incorporate directing groups to control the selectivity. Only a few examples of…

• AP
  Alfred P. Sloan Foundation

  Award: FG-2018-10354
• CA
  Camille and Henry Dreyfus Foundation

  Award: TC-19-019
• NI
  National Institute of General Medical Sciences

  Award: GM-127778
• DO
  Division of Chemistry

  Award: CHE-1654483