Overcoming cancer therapeutic bottleneck by drug repurposing
Sichuan University · State Key Laboratory of Biotherapy · +9 more institutions
Abstract
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing, the development of old drugs for new therapeutic purposes. This strategy with a cost-effective way offers a rare opportunity for the treatment of human neoplastic disease, facilitating rapid clinical translation. With an increased understanding of the hallmarks of cancer and the development of various data-driven approaches, drug repurposing further promotes the holistic productivity of drug discovery and reasonably focuses on target-defined antineoplastic compounds. The "treasure trove" of non-oncology drugs should not be ignored since they could target not…
Citation impact
- FWCI
- 48.24
- Percentile
- 100%
- References
- 530
Authors
7- ZZZhe ZhangCorresponding
Sichuan University, State Key Laboratory of Biotherapy
- LZLi Zhou
Sichuan University, State Key Laboratory of Biotherapy
- NXNa Xie
Sichuan University, State Key Laboratory of Biotherapy
- ECEdouard C. Nice
Monash University
- TZTao Zhang
China National Nuclear Corporation, Chengdu Medical College
Topics & keywords
- Repurposing
- Drug repositioning
- Medicine
- Drug
- Drug discovery
- Drug development
- Cancer
- Intensive care medicine