Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19
Peking University · Peking University People's Hospital · +7 more institutions
Abstract
Abstract An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organs. We have reviewed previously published studies on SARS and recent studies on SARS-CoV-2 infection, named coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO), confirming that many other organs besides the lungs are vulnerable to the virus. ACE2 catalyzes angiotensin II conversion to angiotensin-(1–7), and the ACE2/angiotensin-(1–7)/MAS axis counteracts the negative…
Citation impact
- FWCI
- 24.50
- Percentile
- 100%
- References
- 112
Authors
13- WNWentao NiCorresponding
Peking University, Peking University People's Hospital
- XYXiuwen Yang
Central Hospital of Wuhan, Huazhong University of Science and Technology
- DYDeqing Yang
Peking University, Sichuan University, West China Hospital of Sichuan University, Peking University People's Hospital
- JBJing Bao
Peking University, Peking University People's Hospital
- RLRan Li
Peking University, Peking University People's Hospital
Topics & keywords
- Angiotensin-converting enzyme 2
- Renin–angiotensin system
- Medicine
- Coronavirus
- Angiotensin II
- Virus
- Pneumonia
- Immune system
- Good health and well-being