Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19
Korea Advanced Institute of Science and Technology · Ulsan National Institute of Science and Technology · +6 more institutions
Abstract
Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1β-driven inflammatory response as compared to severe influenza. In classical monocytes from…
Citation impact
- FWCI
- 18.43
- Percentile
- 100%
- References
- 37
Authors
18- JSJeong Seok LeeCorresponding
Korea Advanced Institute of Science and Technology
- SPSeong-Wan ParkCorresponding
Korea Advanced Institute of Science and Technology, Ulsan National Institute of Science and Technology
- HWHye Won JeongCorresponding
Chungbuk National University
- JYJin Young AhnCorresponding
Yonsei University, Severance Hospital
- SJSeong Jin Choi
Korea Advanced Institute of Science and Technology
Topics & keywords
- Coronavirus disease 2019 (COVID-19)
- Immunophenotyping
- 2019-20 coronavirus outbreak
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Virology
- Immunology
- Biology
- Medicine
- Good health and well-being