Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Mathew, Divij; Giles, Josephine R.; Baxter, Amy E.; Oldridge, Derek A.; Greenplate, Allison R.; Wu, Jennifer E.; Alanio, Cécile; Kuri-Cervantes, Leticia; Pampena, M. Betina; D’Andrea, Kurt; Manne, Sasikanth; Chen, Zeyu; Huang, Yinghui; Reilly, John P.; Weisman, Ariel R.; Ittner, C.A.G.; Kuthuru, Oliva; Dougherty, Jeanette; Nzingha, Kito; Han, Nicholas; Kim, Justin; Pattekar, Ajinkya; Goodwin, Eileen C.; Anderson, Elizabeth M.; Weirick, Madison E.; Gouma, Sigrid; Arevalo, Claudia P.; Bolton, Marcus J.; Fang, Chen; Lacey, Simon F.; Ramage, Holly; Cherry, Sara; Hensley, Scott E.; Apostolidis, Sokratis A.; Huang, Alexander C.; Vella, Laura A.; Unit, The UPenn COVID Processing; Betts, Michael R.; Meyer, Nuala J.; Wherry, E. John; Alam, Zahidul; Addison, Mary M.; Byrne, Katelyn T.; Chandra, Aditi; Descamps, Hélène C.; Kaminskiy, Yaroslav; Hamilton, Jacob T.; Noll, Julia Han; Omran, Dalia K.; Perkey, Eric; Prager, Elizabeth M.; Pueschl, Dana; Shah, Jennifer; Shilan, Jake; Vanderbeck, Ashley

doi:10.1126/science.abc8511

articleScienceJul 15, 2020HYBRID OA

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

DMDivij Mathew JRJosephine R. Giles AEAmy E. Baxter DADerek A. Oldridge ARAllison R. Greenplate

Translational Therapeutics (United States) · University of Pennsylvania · +3 more institutions

Indexed incrossref

Abstract

Immune profiling of COVID-19 patients Coronavirus disease 2019 (COVID-19) has affected millions of people globally, yet how the human immune system responds to and influences COVID-19 severity remains unclear. Mathew et al. present a comprehensive atlas of immune modulation associated with COVID-19. They performed high-dimensional flow cytometry of hospitalized COVID-19 patients and found three prominent and distinct immunotypes that are related to disease severity and clinical parameters. Arunachalam et al. report a systems biology approach to assess the immune system of COVID-19 patients with mild-to-severe disease. These studies provide a compendium of immune cell information and roadmaps for potential…

Citation impact

1,652

total citations

FWCI: 36.40
Percentile: 100%
References: 64

Citations per year

Authors

55

Topics & keywords

Topics

Keywords

Coronavirus disease 2019 (COVID-19)
Profiling (computer programming)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Immune system
2019-20 coronavirus outbreak
Virology
Biology
Medicine

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.