Kinetics of viral load and antibody response in relation to COVID-19 severity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent for coronavirus 2019 (COVID-19) pneumonia. Little is known about the kinetics, tissue distribution, cross-reactivity, and neutralization antibody response in patients with COVID-19. Two groups of patients with RT-PCR-confirmed COVID-19 were enrolled in this study: 12 severely ill patients in intensive care units who needed mechanical ventilation and 11 mildly ill patients in isolation wards. Serial clinical samples were collected for laboratory detection. Results showed that most of the severely ill patients had viral shedding in a variety of tissues for 20-40 days after onset of disease (8/12, 66.7%), while the majority of…

• GM
  Guangzhou Medical University
• SK
  State Key Laboratory of Respiratory Disease

  Award: SKLRD-QN-201912
• NN
  National Natural Science Foundation of China

  Awards: 2018YFC1311900, 201912, 2018ZX10301403, N_HKU737/18
• NI
  National Institutes of Health

  Award: P01 060699
• NK
  National Key Research and Development Program of China

  Awards: SARS-CoV-2, 2018YFC1200100, 2018ZX10301403, 2018YFC1311900, 2020YFC0841400
• SA
  Science and Technology Planning Project of Guangdong Province

  Awards: 2019B030316028, 2018B020207013