Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain
University of California, San Francisco · University Memory and Aging Center · +3 more institutions
Abstract
Reversing brain aging may be possible through systemic interventions such as exercise. We found that administration of circulating blood factors in plasma from exercised aged mice transferred the effects of exercise on adult neurogenesis and cognition to sedentary aged mice. Plasma concentrations of glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (Gpld1), a GPI-degrading enzyme derived from liver, were found to increase after exercise and to correlate with improved cognitive function in aged mice, and concentrations of Gpld1 in blood were increased in active, healthy elderly humans. Increasing systemic concentrations of Gpld1 in aged mice ameliorated age-related regenerative and cognitive…
Citation impact
- FWCI
- 33.59
- Percentile
- 100%
- References
- 58
Authors
11Topics & keywords
- Neurogenesis
- Cognition
- Treadmill
- Physical exercise
- Psychology
- Plasma levels
- Endocrinology
- Internal medicine
- Good health and well-being