reviewAntibodiesJul 20, 2020GOLD OA

Monoclonal Antibodies in Cancer Therapy

DJDavid J. ZahaviLMLouis M. Weiner

Georgetown University · Georgetown University Medical Center

PubMed
Indexed incrossrefdoajpubmed

Abstract

Monoclonal antibody-based immunotherapy is now considered to be a main component of cancer therapy, alongside surgery, radiation, and chemotherapy. Monoclonal antibodies possess a diverse set of clinically relevant mechanisms of action. In addition, antibodies can directly target tumor cells while simultaneously promoting the induction of long-lasting anti-tumor immune responses. The multifaceted properties of antibodies as a therapeutic platform have led to the development of new cancer treatment strategies that will have major impacts on cancer care. This review focuses on the known mechanisms of action, current clinical applications for the treatment of cancer, and mechanisms of resistance of monoclonal…

Citation impact

800
total citations
FWCI
43.22
Percentile
100%
References
154
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Monoclonal antibody
  • Immunotherapy
  • Immune system
  • Cancer
  • Antibody
  • Monoclonal antibody therapy
  • Medicine
  • Immunology
UN Sustainable Development Goals
  • Good health and well-being
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