Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Folegatti, Pedro M.; Ewer, Katie; Aley, Parvinder K.; Angus, Brian; Becker, Stephan; Belij‐Rammerstorfer, Sandra; Bellamy, Duncan; Bibi, Sagida; Bittaye, Mustapha; Clutterbuck, Elizabeth; Dold, Christina; Faust, Saul N.; Finn, Adam; Flaxman, Amy; Hallis, Bassam; Heath, Paul T.; Jenkin, Daniel; Lazarus, Rajeka; Makinson, Rebecca; Minassian, Angela M.; Pollock, Katrina M.; Ramasamy, Maheshi; Robinson, Hannah; Snape, Matthew D.; Tarrant, Richard; Voysey, Merryn; Green, Catherine; Douglas, Alexander D.; Hill, Adrian V. S.; Lambe, Teresa; Gilbert, Sarah C.; Pollard, Andrew J.; Aboagye, Jeremy; Adams, K. F.; Ali, Aabidah; Allen, Elizabeth; Allison, Jennifer L.; Anslow, Rachel; Arbe-Barnes, Edward H.; Babbage, Gavin; Baillie, J. Kenneth; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Ballaminut, Juliana; Barnes, Eleanor; Barrett, Jordan R.; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beckley, Rebecca; Berrie, Eleanor; Berry, Lisa; Beveridge, Amy; Bewley, Kevin R.; Bijker, Else M.; Bingham, Tracey; Blackwell, Luke; Blundell, Caitlin L.; Bolam, Emma; Boland, Elena; Borthwick, Nicola; Bower, Thomas; Boyd, Amy; Brenner, Tanja; Bright, Philip; Brown-O’Sullivan, Charlie; Brunt, Emily; Burbage, Jamie; Burge, Sharon; Buttigieg, Karen R.; Byard, Nicholas; Puig, Ingrid Cabera; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Carr, Melanie; Carroll, Miles W.; Carter, Victoria; Cathie, Katrina; Challis, Ruth; Charlton, Sue; Chelysheva, Irina; Cho, Jee-Sun; Cicconi, Paola; Cifuentes, Liliana; Clark, Helen; Clark, Elizabeth; Cole, Tom; Colin-Jones, Rachel; Conlon, Christopher P.; Cook, Aislinn; Coombes, Naomi S.; Cooper, Rachel; Cosgrove, Catherine A.; Coy, Karen; Crocker, Wendy E.M.; Cunningham, Christina J.; Damratoski, Brad E.; Dando, Lynne; Datoo, Mehreen S.; Davies, H. Dele; Graaf, Hans de; Demissie, Tesfaye; Maso, Claudio Di; Dietrich, Isabelle; Dong, Tao; Donnellan, Francesca R.; Douglas, Naomi; Downing, Charlotte; Drake, Jonathan; Drake-Brockman, Rachael; Drury, Ruth; Dunachie, Susanna; Edwards, Nick J.; Edwards, Frances D.L.; Edwards, C J; Elias, Sean C.; Elmore, Michael J.; Emary, Katherine R. W.; English, Marcus Rex; Fagerbrink, Susanne; Felle, Sally; Feng, Shuo; Field, Samantha; Fixmer, Carine; Fletcher, Clare; Ford, Karen; Fowler, Jamie; Fox, Polly; Francis, Emma; Frater, John; Furze, Julie; Fuskova, Michelle; Galiza, Eva; Gbesemete, Diane; Gilbride, Ciarán; Godwin, Kerry; Gorini, Giacomo; Goulston, Lyndsey; Grabau, Caroline; Gracie, Lara; Gray, Zoe; Guthrie, Lucy Belle; Hackett, Mark J.; Halwe, Sandro; Hamilton, Elizabeth; Hamlyn, Joseph; Hanumunthadu, Brama; Harding, Irasha; Harris, Stephanie A.; Harris, Andrew R.; Harrison, Daisy; Harrison, C.P.; Hart, Thomas C.; Haskell, Louise; Hawkins, Sophia; Head, Ian M.; Henry, John A.; Hill, Jennifer; Hodgson, Susanne H.; Hou, Mimi M.; Howe, Elizabeth; Howell, Nicola; Hutlin, Cecilia; Ikram, Sabina; Isitt, Catherine; Iveson, Poppy; Jackson, Susan; Jackson, Frederic; James, William; Jenkins, Megan; Jones, Elizabeth; Jones, Kathryn; Jones, Christine E.; Jones, Bryony A.; Kailath, Reshma; Karampatsas, Konstantinos; Keen, Jade; Kelly, Sarah; Kelly, Dearbhla; Kerr, David; Kerridge, Simon; Khan, Liaquat; Khan, Uzma; Killen, Annabel; Kinch, Jasmin; King, Thomas B.; King, Lloyd D. W.; King, Jade; Kingham-Page, Lucy; Klenerman, Paul; Knapper, Francesca; Knight, Julian C.; Knott, Daniel; Koleva, Stanislava; Kupke, Alexandra; Larkworthy, Colin W.; Larwood, Jessica P. J.; Laskey, Anna; Lawrie, Alison M.; Lee, Arlene; Lee, Kim Yee Ngan; Lees, Emily A.; Legge, Helen; Lelliott, Alice; Lemm, Nana‐Marie; Lias, Amelia M.; Linder, Aline; Lipworth, Samuel; Liu, Xinxue; Liu, Shuchang; Ramon, Raquel Lopez; Lwin, May; Mabesa, Francesca; Madhavan, Meera; Mallett, Garry; Mansatta, Kushal; Marcal, Ines; Marinou, Spyridoula; Marlow, Emma; Marshall, Julia L.; Martin, Jane; McEwan, Joanne; McInroy, Lorna; Meddaugh, Gretchen; Mentzer, Alexander J.; Mirtorabi, Neginsadat; Moore, Maria; Moran, Edward C.; Morey, Ella; Morgan, Victoria; Morris, Susan; Morrison, Hazel; Morshead, Gertraud; Morter, Richard; Mujadidi, Yama F; Muller, Jilly; Múnera‐Huertas, Tatiana; Munro, Claire; Munro, Alasdair; Murphy, Sarah; Munster, Vincent J.; Mweu, Philomena; Noé, Andrés; Nugent, Fay L.; Nuthall, Elizabeth; O’Brien, Katie M.; O’Connor, Daniel; Oguti, Blanché; Oliver, Jennifer L.; Oliveira, Catarina; O’Reilly, Peter; Osborn, Mairead; Osborne, Piper; Owen, Cathy; Owens, DR; Owino, Nelly; Pacurar, Mihaela; Parker, Kaye; Parracho, Helena; Patrick-Smith, Maia; Payne, Victoria; Pearce, Jennifer; Peng, Yanchun; Álvarez, Marco Polo Peralta; Perring, James; Pfafferott, Katja; Pipini, Dimitra; Plested, Emma; Pluess-Hall, Helen; Pollock, Katrina M.; Poulton, Ian; Presland, Laura; Provstgaard-Morys, Samuel; Pulido, David; Radia, Kajal; Lopez, Fernando Ramos; Rand, Jade; Ratcliffe, Helen; Rawlinson, Thomas A.; Rhead, Sarah; Riddell, Amy; Ritchie, Adam; Roberts, Hannah; Robson, Joanna; Roche, Sophie; Rohde, Cornelius; Rollier, Christine S.; Romani, Rossana; Rudiansyah, Indra; Saich, Stephen; Sajjad, Sara; Salvador, Stephannie; Sànchez-Riera, Lídia; Sanders, Helen; Sanders, Katherine; Sapaun, Shari; Sayce, Chloe; Schofield, Ella; Screaton, Gavin; Selby, B.; Semple, Calum; Sharpe, Hannah R.; Shaik, Imam H.; Shea, Adam; Shelton, Holly; Silk, Sarah E.; Silva-Reyes, Laura; Skelly, Donal; Smee, Heather; Smith, Catherine C.; Smith, David J.; Song, Rinn; Spencer, Alexandra J.; Stafford, Elizabeth; Steele, Amy; Stefanova, Elena; Stockdale, Lisa; Szigeti, Anna; Tahiri‐Alaoui, Abdessamad; Tait, Moira; Talbot, H. Keipp; Tanner, Rachel; Taylor, Iona J.; Taylor, Victoria M.; Naudé, Rebecca te Water; Thakur, Nazia; Themistocleous, Yrene; Themistocleous, Andreas C.; Thomas, Merin; Thomas, Tonia M.; Thompson, Amber; Thomson-Hill, Samantha; Tomlins, Jennifer; Tonks, Susan; Towner, James; Tran, Nguyen; Tree, Julia A.; Truby, Adam; Turkentine, Kate; Turner, Cheryl; Turner, Nicola; Turner, Sally; Tuthill, Toby; Ulaszewska, Marta; Varughese, Rachel; Doremalen, Neeltje van; Veighey, Kristin; Verheul, Marije K.; Vichos, Iason; Vitale, Elia; Walker, Laura M.; Watson, Marion; Welham, Benjamin; Wheat, Julie; White, Caroline; White, Rachel; Worth, Andrew; Wright, Danny; Wright, Suzie E; Yao, Xin Li; Yau, Yasmine

doi:10.1016/s0140-6736(20)31604-4

articleThe LancetJul 20, 2020BRONZE OA

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

PMPedro M. Folegatti KEKatie Ewer PKParvinder K. Aley BABrian Angus SBStephan Becker

University of Oxford · Oxford BioMedica (United Kingdom) · +11 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

No abstract available for this paper.

Citation impact

2,614

total citations

FWCI: 60.18
Percentile: 100%
References: 29

Citations per year

Authors

365

PM
Pedro M. FolegattiCorresponding
University of Oxford, Oxford BioMedica (United Kingdom), Jenner Institute
KE
Katie Ewer
University of Oxford, Oxford BioMedica (United Kingdom), Jenner Institute
PK
Parvinder K. Aley
University of Oxford, Oxford BioMedica (United Kingdom)
BA
Brian Angus
University of Oxford, Oxford BioMedica (United Kingdom)
SB
Stephan Becker
Philipps University of Marburg

Topics & keywords

Topics

SARS-CoV-2 and COVID-19 Research99%
Animal Virus Infections Studies0%
vaccines and immunoinformatics approaches0%

Keywords

Reactogenicity
Immunogenicity
Medicine
Vaccination
Neutralization
Virology
Plaque reduction neutralization test
Vaccination schedule

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.

Funding

UR
UK Research and Innovation
Award: MC_PC_19055
CF
Coalition for Epidemic Preparedness Innovations
NI
National Institute for Health and Care Research
Award: MC_PC_19055
UO
University of Oxford
PI
Pirbright Institute
OU
Oxford University Hospitals NHS Foundation Trust
OH
Oxford Health NHS Foundation Trust
MR
Medical Research Council
Award: MR/T001151/1
EA
Engineering and Physical Sciences Research Council
Awards: EP/R013756/1, EP/R013756/1
BA
Biotechnology and Biological Sciences Research Council
Award: BB/S007911/1