Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Consejo Superior de Investigaciones Científicas · Instituto de Agroquímica y Tecnología de Alimentos
Abstract
Ergosterol is an essential component of fungal cell membranes that determines the fluidity, permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a complex and highly energy-consuming pathway that involves the participation of many enzymes. Deficiencies in sterol biosynthesis cause pleiotropic defects that limit cellular proliferation and adaptation to stress. Thereby, fungal ergosterol levels are tightly controlled by the bioavailability of particular metabolites (e.g., sterols, oxygen and iron) and environmental conditions. The regulation of ergosterol synthesis is achieved by overlapping mechanisms that include transcriptional expression, feedback inhibition of enzymes and…
Citation impact
- FWCI
- 18.59
- Percentile
- 100%
- References
- 125
Authors
2Topics & keywords
- Ergosterol
- Saccharomyces cerevisiae
- Sterol
- Biochemistry
- Sterol regulatory element-binding protein
- Biology
- Squalene monooxygenase
- Biosynthesis
- Responsible consumption and production