Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Here, an integrated cascade nanozyme with a formulation of Pt@PCN222-Mn is developed to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide dismutase by incorporation of a Mn-[5,10,15,20-tetrakis(4-carboxyphenyl)porphyrinato]-based metal-organic framework compound capable of transforming oxygen radicals to hydrogen peroxide. The second mimicked functionality is that of catalase by incorporation of Pt nanoparticles, which catalyze hydrogen peroxide disproportionation to water and oxygen. Both in vitro and in vivo experimental measurements reveal the synergistic ROS-scavenging capacity of such an integrated cascade nanozyme. Two forms of inflammatory bowel disease (IBD; i.e.,…

• NN
  National Natural Science Foundation of China

  Awards: 21722503, 21874067
• NS
  Natural Science Foundation of Jiangsu Province

  Award: BK20180340
• FR
  Fundamental Research Funds for the Central Universities

  Award: 14380145