Non-invasive early detection of cancer four years before conventional diagnosis using a blood test

Chen, Xingdong; Gole, Jeffrey; Gore, Athurva; He, Qiye; Lü, Ming; Min, Jun Won; Yuan, Ziyu; Yang, Xiaorong; Jiang, Yanfeng; Zhang, Tiejun; Suo, Chen; Li, Xiaojie; Cheng, Lei; Zhang, Zhenhua; Niu, Hongyu; Li, Zhe; Xie, Zhenhua; Shi, Hanping; Zhang, Xiang; Fan, Min; Wang, Xiaofeng; Yang, Yajun; Dang, Justin; McConnell, C. A.; Zhang, Juan; Wang, Jiucun; Yu, Shun‐Zhang; Ye, Weimin; Gao, Yuan; Zhang, Kun; Liu, Rui; Li, Jin

doi:10.1038/s41467-020-17316-z

articleNature CommunicationsJul 21, 2020GOLD OA

Non-invasive early detection of cancer four years before conventional diagnosis using a blood test

XCXingdong Chen JGJeffrey Gole AGAthurva Gore QHQiye He MLMing Lü

Fudan University · State Key Laboratory of Genetic Engineering · +8 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and were then monitored for cancer occurrence. Here we report the preliminary results of PanSeer, a noninvasive blood test based on circulating tumor DNA methylation, on TZL plasma samples from 605 asymptomatic individuals, 191 of whom were later diagnosed with stomach, esophageal, colorectal, lung or liver cancer within four years of blood draw. We also assay plasma samples from an additional 223…

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Topics & keywords

Topics

Keywords

Blood test
Medicine
Test (biology)
Cancer
Cancer detection
Biology
Internal medicine
Ecology

UN Sustainable Development Goals

Good health and well-being

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