Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model
University College London · Ollscoil na Gaillimhe – University of Galway · +3 more institutions
Abstract
The glymphatic system, that is aquaporin 4 (AQP4) facilitated exchange of CSF with interstitial fluid (ISF), may provide a clearance pathway for protein species such as amyloid-β and tau, which accumulate in the brain in Alzheimer's disease. Further, tau protein transference via the extracellular space, the compartment that is cleared by the glymphatic pathway, allows for its neuron-to-neuron propagation, and the regional progression of tauopathy in the disorder. The glymphatic system therefore represents an exciting new target for Alzheimer's disease. Here we aim to understand the involvement of glymphatic CSF-ISF exchange in tau pathology. First, we demonstrate impaired CSF-ISF exchange and AQP4 polarization…
Citation impact
- FWCI
- 23.05
- Percentile
- 100%
- References
- 63
Authors
15Topics & keywords
- Glymphatic system
- Tauopathy
- Aquaporin 4
- Neuroscience
- Extracellular
- Cerebrospinal fluid
- Alzheimer's disease
- Interstitial fluid
Funding
- ELEli Lilly and Company
- WWellcome
- KCKing’s College London
- WTWellcome TrustAward: 204624/Z/16/Z
- PUParkinson's UKAward: F-1902
- KCKing's College London
- ARAlzheimer’s Research UKAward: ARUK-RF2019A-003
- MRMedical Research CouncilAwards: MR/K026739/1, MR/K026739/1
- EAEngineering and Physical Sciences Research CouncilAwards: MR/K026739/1, EP/N034864/1, EP/N034864/1