The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System
Shiraz University of Medical Sciences · Fasa University of Medical Sciences · +3 more institutions
Abstract
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues…
Citation impact
- FWCI
- 40.36
- Percentile
- 100%
- References
- 291
Authors
5- GDGholamreza Daryabor
Shiraz University of Medical Sciences
- MRMohammad Reza Atashzar
Fasa University of Medical Sciences
- DKDieter Kabelitz
Christian-Albrechts-Universität zu Kiel
- SMSeppo MeriCorresponding
University of Helsinki, Helsinki University Hospital
- KKKurosh KalantarCorresponding
Shiraz University of Medical Sciences
Topics & keywords
- Insulin resistance
- Hyperinsulinemia
- Immune system
- Inflammation
- Metabolic syndrome
- Medicine
- Immunology
- Dyslipidemia
- Good health and well-being