reviewSignal Transduction and Targeted TherapyJul 25, 2020GOLD OA

COVID-19: immunopathogenesis and Immunotherapeutics

YLYang LiSLShasha LiuJLJinyan LiuZZZhixin ZhangXWXiaochun Wan

First Affiliated Hospital of Zhengzhou University · University of Electronic Science and Technology of China · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a critical role in disease pathogenesis and clinical manifestations. SARS-CoV-2 not only activates antiviral immune responses, but can also cause uncontrolled inflammatory responses characterized by marked pro-inflammatory cytokine release in patients with severe COVID-19, leading to lymphopenia, lymphocyte dysfunction, and granulocyte and monocyte abnormalities. These SARS-CoV-2-induced immune abnormalities may lead to infections by microorganisms, septic shock, and…

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947
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18.43
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100%
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84
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Authors

8

Topics & keywords

Topics
Keywords
  • Immunology
  • Immune system
  • Medicine
  • Cytokine storm
  • Disease
  • Immunopathology
  • Pathogenesis
  • Inflammation
UN Sustainable Development Goals
  • Good health and well-being
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