reviewAdvanced Drug Delivery ReviewsJan 1, 2020HYBRID OA

Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LMLisa M. ButlerYPYlenia PeroneJDJonas DehairsLLLeslie LupienVDVincent de Laat

South Australian Health and Medical Research Institute · University of Adelaide · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function as essential building blocks for membranes, serve as fuel to drive energy-demanding processes and play a key role as signaling molecules and as regulators of numerous cellular functions. Not unexpectedly, cancer cells, as well as other cell types in the tumor microenvironment, exploit various ways to acquire lipids and extensively rewire their metabolism as part of a plastic and context-dependent metabolic reprogramming that is driven by both oncogenic and environmental cues. The resulting changes in the fate and composition of lipids help…

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Topics & keywords

Topics
Keywords
  • Lipidomics
  • Context (archaeology)
  • Tumor microenvironment
  • Cancer
  • Cancer cell
  • Biology
  • Lipid metabolism
  • Reprogramming
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