Expanded encyclopaedias of DNA elements in the human and mouse genomes

Abstract The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (…

• NI
  National Institutes of Health

  Awards: U54HG006998, U01HG007036, U41HG007000, UM1HG009442, U54HG007004, U54HG007005, U54HG006997, 10,11
• BA
  Biotechnology and Biological Sciences Research Council

  Award: BB/I025506/1