Exosomes: key players in cancer and potential therapeutic strategy

Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long noncoding RNA, circular RNA, etc., which play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, we mainly summarized as followed: the role of exosome contents in cancer, focusing on proteins and noncoding RNA; the interaction between exosomes and tumor microenvironment; the mechanisms that epithelial-mesenchymal transition, invasion and migration of tumor affected by exosomes;…

• NN
  National Natural Science Foundation of China

  Awards: 2020JJ5381, 81802785, 2020JJ5382
• NS
  Natural Science Foundation of Hunan Province

  Awards: 2020JJ5381, 81802785, 2020JJ5382