reviewJournal of the American Chemical SocietyAug 7, 2020Closed access

Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

CLChunyan LiGCGuangcun ChenYZYejun ZhangFWFeng WuQWQiangbin Wang

Chinese Academy of Sciences · Suzhou Institute of Nano-tech and Nano-bionics · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital imaging capacity in the conventional wavelength range (400-950 nm) has been restricted by its extremely limited tissue penetration. To tackle this challenge, a novel imaging approach using the fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm) has been developed in the past decade to achieve deep penetration and high-fidelity imaging, and thus significant biomedical applications have begun to emerge. In this Perspective, we first examine recent discoveries and challenges in the development of novel NIR-II fluorophores and compatible imaging apparatuses. Subsequently, the recent…

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984
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Authors

5

Topics & keywords

Topics
Keywords
  • Nanotechnology
  • Fluorescence-lifetime imaging microscopy
  • Optical imaging
  • Near-infrared spectroscopy
  • Imaging technology
  • Fluorescence
  • Chemistry
  • Optics
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