Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Stanford University · HKU-Pasteur Research Pole · +7 more institutions
Abstract
Coronavirus disease 2019 (COVID-19) represents a global crisis, yet major knowledge gaps remain about human immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We analyzed immune responses in 76 COVID-19 patients and 69 healthy individuals from Hong Kong and Atlanta, Georgia, United States. In the peripheral blood mononuclear cells (PBMCs) of COVID-19 patients, we observed reduced expression of human leukocyte antigen class DR (HLA-DR) and proinflammatory cytokines by myeloid cells as well as impaired mammalian target of rapamycin (mTOR) signaling and interferon-α (IFN-α) production by plasmacytoid dendritic cells. By contrast, we detected enhanced plasma levels of inflammatory…
Citation impact
- FWCI
- 26.90
- Percentile
- 100%
- References
- 44
Authors
31- PSPrabhu S. ArunachalamCorresponding
Stanford University
- FWFlorian WimmersCorresponding
Stanford University
- CKChris Ka Pun MokCorresponding
HKU-Pasteur Research Pole, University of Hong Kong
- RARanawaka A. P. M. PereraCorresponding
HKU-Pasteur Research Pole, University of Hong Kong
- MSMadeleine ScottCorresponding
Stanford Medicine, Stanford University
Topics & keywords
- Coronavirus disease 2019 (COVID-19)
- Immunity
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- 2019-20 coronavirus outbreak
- Virology
- Betacoronavirus
- Biology
- Immunology
- Good health and well-being