The MRC IEU OpenGWAS data infrastructure

Abstract Data generated by genome-wide association studies (GWAS) are growing fast with the linkage of biobank samples to health records, and expanding capture of high-dimensional molecular phenotypes. However the utility of these efforts can only be fully realised if their complete results are collected from their heterogeneous sources and formats, harmonised and made programmatically accessible. Here we present the OpenGWAS database, an open source, open access, scalable and high-performance cloud-based data infrastructure that imports and publishes complete GWAS summary datasets and metadata for the scientific community. Our import pipeline harmonises these datasets against dbSNP and the human genome…

• WT
  Wellcome Trust

  Awards: 209739/Z/17/Z, Z/17/Z, 208806/Z/17/Z
• UH
  University Hospitals Bristol NHS Foundation Trust
• CR
  Cancer Research UK

  Awards: MC_UU_00011/1, C18281/A19169, A19169, C18281, C52724/A20138, MC_UU_00011/4
• NI
  National Institute for Health and Care Research

  Awards: C18281/A19169, MC_UU_00011/4, MC_UU_00011/1
• BH
  British Heart Foundation

  Awards: MC_UU_00011/1, AA/18/7/34219
• UO
  University of Bristol

  Awards: MC_UU_00011/4, C18281/A19169, MC_UU_00011/1
• MR
  Medical Research Council

  Awards: MC_UU_00011/4, MC_UU_00011/1, MC_UU_00011/1, MC_UU_00011