Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
Democritus University of Thrace · University Hospital of Alexandroupolis · +5 more institutions
Abstract
Emerging data indicate that complement and neutrophils contribute to the maladaptive immune response that fuels hyperinflammation and thrombotic microangiopathy, thereby increasing coronavirus 2019 (COVID-19) mortality. Here, we investigated how complement interacts with the platelet/neutrophil extracellular traps (NETs)/thrombin axis, using COVID-19 specimens, cell-based inhibition studies, and NET/human aortic endothelial cell (HAEC) cocultures. Increased plasma levels of NETs, tissue factor (TF) activity, and sC5b-9 were detected in patients. Neutrophils of patients yielded high TF expression and released NETs carrying active TF. Treatment of control neutrophils with COVID-19 platelet-rich plasma generated…
Citation impact
- FWCI
- 49.22
- Percentile
- 100%
- References
- 34
Authors
17- PSPanagiotis Skendros
Democritus University of Thrace, University Hospital of Alexandroupolis
- AMAlexandros Mitsios
Democritus University of Thrace
- ACAkrivi Chrysanthopoulou
Democritus University of Thrace
- DCDimitrios C. Mastellos
National Centre of Scientific Research "Demokritos"
- SMSymeon Metallidis
Aristotle University of Thessaloniki, AHEPA University Hospital
Topics & keywords
- Neutrophil extracellular traps
- Complement system
- Thrombotic microangiopathy
- Thrombogenicity
- Platelet
- Tissue factor
- Immunology
- Complement component 5
- Good health and well-being