Staphylococcal Biofilm Development: Structure, Regulation, and Treatment Strategies

, the most frequent causes of biofilm-associated infections on indwelling medical devices, can switch between an existence as single free-floating cells and multicellular biofilms. During biofilm formation, cells first attach to a surface and then multiply to form microcolonies. They subsequently produce the extracellular matrix, a hallmark of biofilm formation, which consists of polysaccharides, proteins, and extracellular DNA. After biofilm maturation into three-dimensional structures, the biofilm community undergoes a disassembly process that leads to the dissemination of staphylococcal cells. As biofilms are dynamic and complex biological systems, staphylococci have evolved a vast network of regulatory…

• UD
  U.S. Department of Veterans Affairs
• AH
  American Heart Association

  Award: 20POST35220011
• SN
  Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

  Award: P2ZHP3_168570
• NI
  National Institute of Allergy and Infectious Diseases

  Award: AI083211