reviewJournal of Hematology & OncologyAug 10, 2020GOLD OA

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

RTRong TangJXJin XuBZBo ZhangJLJiang LiuCLChen Liang

Shanghai Medical College of Fudan University · Fudan University Shanghai Cancer Center · +1 more institution

PubMed
Indexed incrossrefdoajpubmed

Abstract

In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by the fact that only one third of patients with most types of cancer respond to these agents. The induction of cell death mechanisms other than apoptosis has gradually emerged as a new cancer treatment strategy because most tumors harbor innate resistance to apoptosis. However, to date, the possibility of combining these two modalities has not been discussed systematically. Recently, a few studies revealed crosstalk between distinct cell death mechanisms and antitumor immunity. The induction of pyroptosis, ferroptosis, and necroptosis…

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1,347
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115.95
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100%
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Authors

9

Topics & keywords

Topics
Keywords
  • Pyroptosis
  • Necroptosis
  • Programmed cell death
  • Immunogenic cell death
  • Granzyme
  • Oncolytic virus
  • Cancer research
  • Immunotherapy
UN Sustainable Development Goals
  • Good health and well-being
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