Allostatic Load and Its Impact on Health: A Systematic Review

Allostatic load refers to the cumulative burden of chronic stress and life events. It involves the interaction of different physiological systems at varying degrees of activity. When environmental challenges exceed the individual ability to cope, then allostatic overload ensues. Allostatic load is identified by the use of biomarkers and clinical criteria.

To summarize the current knowledge on allostatic load and overload and its clinical implications based on a systematic review of the literature.