The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Jinan University · Southern University of Science and Technology · +5 more institutions
Abstract
Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting AMPK signaling, a key singular node of cellular metabolism. Recent studies have shown that AMPK signaling can also reversibly regulate hyperactive MAPK signaling in cancer cells by phosphorylating its key components, RAF/KSR family kinases, which affects not only…
Citation impact
- FWCI
- 20.84
- Percentile
- 100%
- References
- 295
Authors
4- JYJimin YuanCorresponding
Jinan University, Southern University of Science and Technology, Southern Medical University Shenzhen Hospital, Shenzhen Second People's Hospital
- XDXiaoduo Dong
ShenZhen People’s Hospital
- JYJiajun Yap
Duke-NUS Medical School
- JHJiancheng Hu
Duke-NUS Medical School, National Cancer Centre Singapore
Topics & keywords
- MAPK/ERK pathway
- AMPK
- Carcinogenesis
- Cancer research
- Signal transduction
- Cancer
- Protein kinase A
- Cancer cell
- Good health and well-being