Prognostic value of depression and anxiety on breast cancer recurrence and mortality: a systematic review and meta-analysis of 282,203 patients

Depression and anxiety are common comorbidities in breast cancer patients. Whether depression and anxiety are associated with breast cancer progression or mortality is unclear. Herein, based on a systematic literature search, 17 eligible studies involving 282,203 breast cancer patients were included. The results showed that depression was associated with cancer recurrence [1.24 (1.07, 1.43)], all-cause mortality [1.30 (1.23, 1.36)], and cancer-specific mortality [1.29 (1.11, 1.49)]. However, anxiety was associated with recurrence [1.17 (1.02, 1.34)] and all-cause mortality [1.13 (1.07, 1.19)] but not with cancer-specific mortality [1.05 (0.82, 1.35)]. Comorbidity of depression and anxiety is associated with…

• GP
  Guangdong Provincial Hospital of Traditional Chinese Medicine

  Awards: 81873306, 81703764, 81703749, 20181132, 2018KZDXM022, 2016A030306025, YN2018MJ07, 201904010407, 2018A030310506, YN2018QJ08, 20182044, 2017B030314166, 2017A030310213, 81573651, A1-2606-19-111-009, A1-3002-16-111-003
• NN
  National Natural Science Foundation of China

  Awards: A1-3002-16-111-003, 2016A030306025, 81703749, 81703764, 81573651, 2018KZDXM022, 81873306, 20181132, YN2018QJ08, YN2018MJ07, 81973526, A1-2606-19-111-009, 201904010407, 2017A030310213, 2017B030314166, 20182044, 2018A030310506
• NS
  Natural Science Foundation of Guangdong Province

  Awards: A1-3002-16-111-003, 2017B030314166, 81573651, 2017A030310213, 2018KZDXM022, 81703749, 20181132, YN2018MJ07, A1-2606-19-111-009, YN2018QJ08, 81703764, 2016A030306025, 20182044, 2018A030310506, 201904010407, 81873306
• DO
  Department of Education of Guangdong Province

  Awards: A1-2606-19-111-009, 81703749, 2016A030306025, 2017A030310213, 81573651, A1-3002-16-111-003, 20181132, 2018KZDXM022, 2017B030314166, 20182044, YN2018QJ08, 2018A030310506, 81703764, 201904010407, YN2018MJ07, 81873306
• GU
  Guangzhou University of Chinese Medicine
• GU
  Guangzhou University
• SA
  Science and Technology Planning Project of Guangdong Province

  Award: 2017B030314166