hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets
Huazhong University of Science and Technology · Union Hospital
Abstract
Transcription factors (TFs) as key regulators play crucial roles in biological processes. The identification of TF-target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene expression. The accumulated data of chromatin immunoprecipitation sequencing (ChIP-seq) provide great opportunities to discover the TF-target regulations across different conditions. In this study, we constructed a database named hTFtarget, which integrated huge human TF target resources (7190 ChIP-seq samples of 659 TFs and high-confidence binding sites of 699 TFs) and epigenetic modification information to predict accurate TF-target regulations. hTFtarget offers the following functions for…
Citation impact
- FWCI
- 20.42
- Percentile
- 100%
- References
- 32
Authors
7- QZQiong Zhang
Huazhong University of Science and Technology
- WLWei Liu
Union Hospital, Huazhong University of Science and Technology
- HZHongmei Zhang
Huazhong University of Science and Technology
- GXGui‐Yan Xie
Huazhong University of Science and Technology
- YMYa‐Ru Miao
Huazhong University of Science and Technology
Topics & keywords
- Database
- Computer science
- Computational biology
- Business
- Biology