Neutralizing Antibodies Correlate with Protection from SARS-CoV-2 in Humans during a Fishery Vessel Outbreak with a High Attack Rate
University of Washington · University of Washington Medical Center · +2 more institutions
Abstract
The development of vaccines against SARS-CoV-2 would be greatly facilitated by the identification of immunological correlates of protection in humans. However, to date, studies on protective immunity have been performed only in animal models and correlates of protection have not been established in humans. Here, we describe an outbreak of SARS-CoV-2 on a fishing vessel associated with a high attack rate. Predeparture serological and viral reverse transcription-PCR (RT-PCR) testing along with repeat testing after return to shore was available for 120 of the 122 persons on board over a median follow-up of 32.
Citation impact
- FWCI
- 14.08
- Percentile
- 100%
- References
- 59
Authors
9- AAAmin AddetiaCorresponding
University of Washington
- KHKatharine H. D. Crawford
University of Washington, University of Washington Medical Center, Fred Hutch Cancer Center
- ASAdam S. Dingens
Fred Hutch Cancer Center
- HZHaiying Zhu
University of Washington
- PRPavitra Roychoudhury
University of Washington, Fred Hutch Cancer Center
Topics & keywords
- Outbreak
- Serology
- Attack rate
- Virology
- Biology
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Immunity
- Antibody
- Life below water