Short chain fatty acids in human gut and metabolic health
Maastricht University · Maastricht School of Management · +17 more institutions
Abstract
Evidence is accumulating that short chain fatty acids (SCFA) play an important role in the maintenance of gut and metabolic health. The SCFA acetate, propionate and butyrate are produced from the microbial fermentation of indigestible carbohydrates and appear to be key mediators of the beneficial effects elicited by the gut microbiome. Microbial SCFA production is essential for gut integrity by regulating the luminal pH, mucus production, providing fuel for epithelial cells and effects on mucosal immune function. SCFA also directly modulate host metabolic health through a range of tissue-specific mechanisms related to appetite regulation, energy expenditure, glucose homeostasis and immunomodulation. Therefore,…
Citation impact
- FWCI
- 56.79
- Percentile
- 100%
- References
- 160
Authors
13- EEEllen E. BlaakCorresponding
Maastricht University
- EEEmanuel E. Canfora
Maastricht School of Management, Maastricht University
- STStephan Theis
Südzucker (Germany)
- GFGary Frost
Imperial College London
- AKAlbert K. Groen
University Medical Center Groningen, University of Groningen, Amsterdam University Medical Centers
Topics & keywords
- Human health
- Food science
- Biochemistry
- Biology
- Chemistry
- Biotechnology
- Medicine
- Environmental health