reviewCellsAug 26, 2020GOLD OA

Mechanisms of IGF-1-Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy

TYTadashi YoshidaPDPatrice Delafontaine

Tulane University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Insulin-like growth factor-1 (IGF-1) is a key growth factor that regulates both anabolic and catabolic pathways in skeletal muscle. IGF-1 increases skeletal muscle protein synthesis via PI3K/Akt/mTOR and PI3K/Akt/GSK3β pathways. PI3K/Akt can also inhibit FoxOs and suppress transcription of E3 ubiquitin ligases that regulate ubiquitin proteasome system (UPS)-mediated protein degradation. Autophagy is likely inhibited by IGF-1 via mTOR and FoxO signaling, although the contribution of autophagy regulation in IGF-1-mediated inhibition of skeletal muscle atrophy remains to be determined. Evidence has suggested that IGF-1/Akt can inhibit muscle atrophy-inducing cytokine and myostatin signaling via inhibition of the…

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666
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100%
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Authors

2

Topics & keywords

Topics
Keywords
  • Skeletal muscle
  • PI3K/AKT/mTOR pathway
  • Protein kinase B
  • Muscle atrophy
  • Autophagy
  • Myostatin
  • Muscle hypertrophy
  • Biology
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