SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Shanghai Medical College of Fudan University · Fudan University · +6 more institutions
Abstract
Critically ill patients diagnosed with COVID-19 may develop a pro-thrombotic state that places them at a dramatically increased lethal risk. Although platelet activation is critical for thrombosis and is responsible for the thrombotic events and cardiovascular complications, the role of platelets in the pathogenesis of COVID-19 remains unclear.
-induced thrombus formation in vivo, and thrombus formation under flow conditions ex vivo.
Citation impact
- FWCI
- 14.88
- Percentile
- 100%
- References
- 92
Authors
17- SZSi ZhangCorresponding
Shanghai Medical College of Fudan University, Fudan University, Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University
- YLYangyang Liu
First Affiliated Hospital of Zhengzhou University
- XWXiaofang Wang
First Affiliated Hospital of Zhengzhou University
- YLYang Li
First Affiliated Hospital of Zhengzhou University
- HLHaishan Li
Anhui Medical University
Topics & keywords
- Coronavirus disease 2019 (COVID-19)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Hematology
- 2019-20 coronavirus outbreak
- Platelet
- Thrombosis
- Medicine
- Virology
- Good health and well-being