Circadian control of brain glymphatic and lymphatic fluid flow

The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to vascular endfeet of astrocytes. The glymphatic system is more effective during sleep, but whether sleep timing promotes glymphatic function remains unknown. We here show glymphatic influx and clearance exhibit endogenous, circadian rhythms peaking during the mid-rest phase of mice. Drainage of CSF from the cisterna magna to the lymph nodes exhibits daily variation opposite to glymphatic influx, suggesting distribution of CSF throughout the animal depends on…

• UD
  U.S. Department of Defense

  Award: W911NF1910280
• FL
  Fondation Leducq
• NN
  Novo Nordisk
• HL
  H. Lundbeck A/S
• NI
  National Institutes of Health

  Awards: RF1AG057575, W911NF1910280, R01NS100366
• UA
  U.S. Army

  Awards: MURI W911NF1910280, W911NF1910280
• MU
  Multidisciplinary University Research Initiative

  Award: W911NF1910280
• NI
  National Institute of Neurological Disorders and Stroke

  Awards: R01NS100366, RF1AG057575
• RD
  Research, Development and Engineering Command
• AR
  Army Research Office

  Awards: MURI W911NF1910280, W911NF1910280