FGF/FGFR signaling in health and disease

Xie, Yangli; Su, Nan; Yang, Jing; Tan, Qiaoyan; Huang, Shuo; Jin, Min; Ni, Zhenhong; Zhang, Bin; Zhang, Dali; Luo, Fengtao; Chen, Hangang; Sun, Xianding; Feng, Jian Q.; Qi, Huabing; Chen, Lin

doi:10.1038/s41392-020-00222-7

reviewSignal Transduction and Targeted TherapySep 2, 2020GOLD OA

FGF/FGFR signaling in health and disease

YXYangli Xie NSNan Su JYJing Yang QTQiaoyan Tan SHShuo Huang

Army Medical University · Daping Hospital · +1 more institution

PubMed

Indexed incrossrefdoajpubmed

Abstract

Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR) signaling has crucial roles in a multitude of processes during embryonic development and adult homeostasis by regulating cellular lineage commitment, differentiation, proliferation, and apoptosis of various types of cells. In this review, we provide a comprehensive overview of the current understanding of FGF signaling and its roles in organ development, injury repair, and the pathophysiology of spectrum of diseases, which is a consequence of FGF signaling dysregulation, including cancers and chronic kidney disease (CKD). In this context, the agonists and antagonists for FGF-FGFRs might have therapeutic benefits in multiple…

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868

total citations

FWCI: 31.01
Percentile: 100%
References: 763

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Authors

15

Topics & keywords

Topics

Keywords

Fibroblast growth factor
Fibroblast growth factor receptor
Context (archaeology)
Signal transduction
Biology
Fibroblast growth factor 23
Disease
Cancer research

UN Sustainable Development Goals

Good health and well-being

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