DynaMut2 : Assessing changes in stability and flexibility upon single and multiple point missense mutations
Baker Heart and Diabetes Institute · The University of Melbourne · +2 more institutions
Abstract
Abstract Predicting the effect of missense variations on protein stability and dynamics is important for understanding their role in diseases, and the link between protein structure and function. Approaches to estimate these changes have been proposed, but most only consider single‐point missense variants and a static state of the protein, with those that incorporate dynamics are computationally expensive. Here we present DynaMut2, a web server that combines Normal Mode Analysis (NMA) methods to capture protein motion and our graph‐based signatures to represent the wildtype environment to investigate the effects of single and multiple point mutations on protein stability and dynamics. DynaMut2 was able to…
Citation impact
- FWCI
- 20.50
- Percentile
- 100%
- References
- 67
Authors
3- CHCarlos H. M. Rodrigues
Baker Heart and Diabetes Institute, The University of Melbourne, Melbourne Bioinformatics
- DEDouglas E. V. PiresCorresponding
Baker Heart and Diabetes Institute, The University of Melbourne, Melbourne Bioinformatics
- DBDavid B. AscherCorresponding
Baker Heart and Diabetes Institute, The University of Melbourne, University of Cambridge, Melbourne Bioinformatics
Topics & keywords
- Missense mutation
- Point mutation
- Computer science
- Computational biology
- Molecular dynamics
- Stability (learning theory)
- Genetics
- Biology
- Affordable and clean energy