The impact of sex on gene expression across human tissues
Chicago Department of Public Health · University of Chicago · +26 more institutions
Abstract
Many complex human phenotypes exhibit sex-differentiated characteristics. However, the molecular mechanisms underlying these differences remain largely unknown. We generated a catalog of sex differences in gene expression and in the genetic regulation of gene expression across 44 human tissue sources surveyed by the Genotype-Tissue Expression project (GTEx, v8 release). We demonstrate that sex influences gene expression levels and cellular composition of tissue samples across the human body. A total of 37% of all genes exhibit sex-biased expression in at least one tissue. We identify cis expression quantitative trait loci (eQTLs) with sex-differentiated effects and characterize their cellular origin. By…
Citation impact
- FWCI
- 63.78
- Percentile
- 100%
- References
- 106
Authors
212- MOMeritxell OlivaCorresponding
Chicago Department of Public Health, University of Chicago
- MMManuel Muñoz-AguirreCorresponding
Centre for Genomic Regulation, Universitat Politècnica de Catalunya
- SKSarah Kim-HellmuthCorresponding
Max Planck Institute of Psychiatry, New York Genome Center, Columbia University
- VWValentin Wucher
Centre for Genomic Regulation
- ADAriel DH Gewirtz
Princeton University
Topics & keywords
- Expression quantitative trait loci
- Biology
- Gene expression
- Gene
- Transcriptome
- Genetics
- Regulation of gene expression
- Phenotype