GSH‐Depleted Nanozymes with Hyperthermia‐Enhanced Dual Enzyme‐Mimic Activities for Tumor Nanocatalytic Therapy

Abstract Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an emerging technology for therapeutic treatment of various malignant tumors. However, the relatively deficient catalytic activity of nanozymes in the tumor microenvironment (TME) restrains their biomedical applications. Here, a versatile and bacteria‐like PEG/Ce‐Bi@DMSN nanozyme is developed by coating uniform Bi 2 S 3 nanorods (NRs) with dendritic mesoporous silica (Bi 2 S 3 @DMSN) and then decorating ultrasmall ceria nanozymes into the large mesopores of Bi 2 S 3 @DMSN. The nanozymes exhibit dual enzyme‐mimic catalytic activities (peroxidase‐mimic and catalase‐mimic) under acidic conditions that can regulate the TME,…

• NN
  National Natural Science Foundation of China

  Awards: 51929201, 51720105015, 51602072, 51972075, 51772059
• NS
  Natural Science Foundation of Heilongjiang Province

  Award: YQ2019E014
• FR
  Fundamental Research Funds for the Central Universities