Determinants of telomere length across human tissues
Chicago Department of Public Health · University of Chicago · +9 more institutions
Abstract
Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue types, and associations with age and ancestry. We show that genetic variation affects TL in multiple tissue types and that TL may mediate the effect of age on gene expression. Our results provide the foundational knowledge…
Citation impact
- FWCI
- 32.12
- Percentile
- 100%
- References
- 71
Authors
194- KDKathryn DemanelisCorresponding
Chicago Department of Public Health, University of Chicago
- FJFarzana Jasmine
Chicago Department of Public Health, University of Chicago
- LCLin Chen
Chicago Department of Public Health, University of Chicago
- MCMeytal Chernoff
Chicago Department of Public Health, University of Chicago
- TLTong Lin
Chicago Department of Public Health, University of Chicago
Topics & keywords
- Telomere
- Biology
- Biological age
- Biomarker
- Genotype
- Correlation
- Disease
- Genetic variation
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