SARS-CoV-2–triggered neutrophil extracellular traps mediate COVID-19 pathology
Universidade de São Paulo · Universidade do Sul de Santa Catarina
Abstract
Severe COVID-19 patients develop acute respiratory distress syndrome that may progress to cytokine storm syndrome, organ dysfunction, and death. Considering that neutrophil extracellular traps (NETs) have been described as important mediators of tissue damage in inflammatory diseases, we investigated whether NETs would be involved in COVID-19 pathophysiology. A cohort of 32 hospitalized patients with a confirmed diagnosis of COVID-19 and healthy controls were enrolled. The concentration of NETs was augmented in plasma, tracheal aspirate, and lung autopsies tissues from COVID-19 patients, and their neutrophils released higher levels of NETs. Notably, we found that viable SARS-CoV-2 can directly induce the…
Citation impact
- FWCI
- 60.51
- Percentile
- 100%
- References
- 56
Authors
46Topics & keywords
- Neutrophil extracellular traps
- Coronavirus disease 2019 (COVID-19)
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- 2019-20 coronavirus outbreak
- Extracellular
- Betacoronavirus
- Sars virus
- Virology
- Good health and well-being